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Our assessment of this cohort would be that the scientific activity of MCLA-129 in 2nd line head and neck most cancers appears substantially inferior to that of our direct asset petosemtamab, and only on par with other EGFR or cetuximab-centered monoclonal or bispecific antibodies as monotherapy in a similar environment. We consider this efficacy is insufficient to warrant more progress in head and neck most cancers.
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The third century Advertisement marked a serious decrease in Asia stemming in part from epidemic illness, beginning Using the Antonine plague, the indiscipline of nearby soldiers and also the diminishing instances of voluntary civic generosity.
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The truth is, Asia province was exclusive in that it had been one of several number of ungarrisoned provinces on the empire. Even though no total legions have been ever stationed inside the province, that is not to state that there was no army presence go here in anyway.[eleven]
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† Italy was by no means constituted as being a province, instead retaining a Unique juridical standing until finally Diocletian's reforms.